Initiatives & Networks

The following are key PopMedNet initiatives and networks:

PCORnet LogoPCORnet (PCORI) - The National Patient-Centered Clinical Research Network's goal is to improve the nation's capacity to conduct comparative effectiveness research efficiently by creating a large, highly representative network for conducting clinical outcomes research. PopMedNetTM is the platform for the PCORnet Distributed Research Network which will facilitate multi-site patient-centered research across Clinical Data Research Networks (CDRNs), Patient Powered Research Networks (PPRNs), and other interested contributors. Over 70 organizations participate in 29 CDRNs and PPRNs.
FDA's Sentinel Initiative (FDA) - In the fall of 2007, Congress passed the FDA Amendments Act (FDAAA), mandating the FDA to establish an Active Post-Market Risk Identification and Analysis (ARIA). FDAAA requires the FDA to develop, in collaboration with public, academic, and private entities, methods to obtain access to disparate data sources and validated methods for the establishment of a system to link and analyze safety data from multiple sources. In May 2008, the FDA launched the Sentinel Initiative to create a national electronic system, the Sentinel System, for medical product safety surveillance.

The first phase of this initiative was the Mini-Sentinel Pilot to inform the development of the Sentinel System. In 2008, FDA awarded Harvard Pilgrim Health Care Institute a contract for the Mini-Sentinel pilot. HPHCI developed a distributed data network based on PopMedNet to meet the goals and objectives of FDA’s Sentinel Initiative. In September 2014, the FDA began transitioning from the Mini-Sentinel pilot phase to the full Sentinel System, which officially launched in February 2016. HPHCI serves as the prime contractor for FDA Sentinel and is responsible for all aspects of the distributed network, including secure hosting and maintenance, development of analytic tools and query capability, and sending queries to partners to answer FDA safety questions.
MDPHnet LogoMDPHNet (ONC; State Health Information Exchange Program) - This Office of the National Coordinator for Health IT funded project with the Massachusetts eHealth Institute will adapt the PopMedNet™ software to create MDPHNet; a population-based electronic health record surveillance network targeting a broad array of health indicators across multiple providers and delivery systems. The project will integrate PopMedNet™ and ESP into a single approach for population-based surveillance. Data partners for this network include the Massachusetts League of Community Health Centers, Atrius Health, and Cambridge Health Alliance.
NIH DRN LogoNIH Health Care Systems Research Collaboratory Distributed Research Network (NIH) – The NIH Distributed Research Network aims to facilitate multi-site clinical research collaborations inside health care systems. The Collaboratory supports the design and rapid execution of several high impact pragmatic clinical trial demonstration projects that will address questions of major public health importance. Data partners include Aetna, Group Health, Harvard Pilgrim Health Care, Health Partners, Henry Ford, Humana, Kaiser Permanente Northwest, Mayo Clinic, and the University of Washington.
HCSRN LogoHealth Care Systems Research Network Distributed Query Tool (HCSRNnet) – the Health Care Systems Research Network Distributed Query Tool facilitates prepatory-to-research and feasibility querying among health insurers and integrated delivery systems. Data partners include Geisinger, Group Health, Harvard Pilgrim Health Care, Henry Ford, Kaiser Permanente Colorado, Kaiser Permanente Hawaii, Kaiser Permanente Mid-Atlantic, Kaiser Permanente Northern California, Kaiser Permanente Northwest, Kaiser Permanente Southeast, Marshfield Clinic Research Foundation, Meyers Primary Care Institute, and Palo Alto Medical Foundation Research Institute.
CRN LogoHMO Cancer Research Network (CRN) – Nested within HMORNnet, the Cancer Research Network (CRN) is a consortium of nine nonprofit research centers based in integrated health care delivery organizations. Collectively, these organizations provide care to nearly 10 million individuals. To search the CRN publications database, please visit
CHORDS LogoColorado Health Observations Regional Data Service (CHORDS) is a collaboration between several affiliated research and health care organizations in the Colorado region. Its purpose is establish and maintain technical and policy infrastructure to facilitate regional data sharing for cohort discovery, cost/quality research initiatives, regional health surveillance, and targeted primary care interventions to support public health.
SPAN LogoScalable PArtnering Network for CER: Across Lifespan, Conditions, and Settings (AHRQ) - The Scalable PArtnering Network for CER: Across Lifespan, Conditions, and Settings (SPAN) leveraged and enhanced the PopMedNetTM software to conduct comparative effectiveness research over a range of health care systems and sites and based on patient-reported outcomes from obesity and ADHD cohorts. Data partners for this network included: Kaiser Permanente Colorado, Geisinger, Group Health, Harvard Pilgrim Health Care Institute, Health Partners, Kaiser Permanente Hawaii, Kaiser Permanente Northwest, Kaiser Permanente North Carolina, Kaiser Permanente Georgia, Denver Health, and Essentia Institute of Rural Health.
PEAL LogoThe Population-Based Effectiveness in Asthma and Lung Diseases Network (AHRQ) - The Population-based Effectiveness in Asthma and Lung Diseases (PEAL) project worked to better elucidate the factors that affect prescribing and adherence to asthma controller medications in diverse populations.  The project utilized PopMedNetTM software for secure file transfers and distributed analytics. Data partners for this network included: Health Partners, Harvard Pilgrim Health Care Institute, Kaiser Permanente Georgia, Kaiser Permanente North Carolina, and Vanderbilt.
Query Health Initiative (ONC) - This Office of the National Coordinator for Health IT initiative is developing national standards for electronic health records in order to address population medicine queries. The PopMedNet™ system was presented in the Summer Concert Series in 2011, and the architecture has been incorporated into the Query Health distributed querying Technical Approach and was used in a proof-of-concept
Expansion of the DEcIDE Distributed Research Network (DRN) Infrastructure to Support Studies of Comparative Effectiveness – Part II (AHRQ) - Enhanced and implemented the distributed research network prototype created in Phase 1, to support patient-centered studies and collaborative research on comparative effectiveness. Data partners for this network included: Harvard Pilgrim Health Care Institute, Geisinger, Group Health, Kaiser Permanente Colorado, Health Partners, and Kaiser Permanente Colorado.
Developing a Distributed Research Network to Conduct Population-based Studies and Safety Surveillance - Phase 1 (AHRQ) - Developed a distributed research network prototype to support the secure analyses of health information across multiple organizations to facilitate the study of the clinical effectiveness of various medical therapies.
Other Collaborations
Other Collaborations
In addition to FDA Sentinel and PCORnet, HPHCI serves as the coordinating center for several other initiatives that use PMN and the associated software ecosystem. These include the Biologics and Biosimilars Collective Intelligence Consortium (BBCIC) and IMEDS. The BBCICwas established in 2015 to address anticipated needs for post-marketed evidence generation for novel biologics, their corresponding biosimilars and other related products. IMEDS is a program of the Reagan-Udall Foundation established to provide access for private-sector entities, such as regulated industry, academic institutions, and non-profit organizations, to a system based on the FDA Sentinel Initiative. HPHCI serves as the IMEDS Analytic Coordinating Center and is responsible for secure hosting of the IMEDS network, sending queries to the participating data partners and aggregating results. Further, HPHCI holds several software development contracts with other funders (e.g., Assistant Secretary for Planning and Evaluation [ASPE]) that build on PMN capabilities.